***Enhancing trigger sensitivity of nanocarriers through organocatalytic oxidant activation***

 Authors: I. Piergentili(a), M. Cai(b), B. Klemm(a), B. Xu(c), S. Luo(b), and R. Eelkema(a)

a Delft University of Technology, Department of Chemical Engineering, Van der Maasweg 9, 2629 HZ Delft, The Netherlands

b Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing100084, China

c Delft University of Technology, Department of Radiation Science and Technology, Mekelweg 15, 2629 JB Delft, The Netherlands

Corresponding author: R. Eelkema

Contact Information: 

r.eelkema@tudelft.nl

Delft University of Technology - Department of Chemical Engineering

Van der Maasweg 9

2629 HZ Delft

The Netherlands

***General Introduction*** 

This dataset contains data underlying the publication: Enhancing trigger sensitivity of nanocarriers through organocatalytic oxidant activation"

collected as part of Irene Piergentili's PhD Thesis project. It is being made public to act as supplementary data for the publication and additionally for the PhD thesis of Irene Piergentili. 

These data were made available for other researchers to use in their own work. The data in this data set was collected in the Department of Chemical Engineering and Department of Radiation Science and Technology of the Delft University of Technology - Faculty of Applied Science, between March 2021 and January 2023. 

This research project was made possible by a grant from the Netherlands Organisation for Scientific Research and the National Natural Science Foundation of China (NWO-NSFC joint project).

***Purpose of the work*** 

The purpose of these experiments was to investigate the use of organocatalysis on thioanisole ester based micelles as oxidation-sensitive drug delivery and release carrier.

***Equipment***

Thioanisole ester based micelles in presence of organocatalysis were investigated via several techniques: Nuclear Magnetic Resonance (NMR), Dynamic Light Scattering (DLS)and Fluorescence Spectroscopy. Specifications on instruments details and method used can be find in the ESI, available with the preprint (https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4351031).

***Description of the data in this data set***

The data included in this data set have been organised per technique and figure number as reported in the publication and in the corresponding ESI. The name of each data set is typically: _FigureX_Experimental technique.fileformat

NMR data are provided as raw unprocessed .fid data files as well as log text files containing time of measurement information in NMR_Figure 3

DLS data are provided as an output from Malvern Zetasizer including information around scatter count, Z-average diameter, Intensity and Number plots, Number average size (Figure 4A_S5A_DLS and Figure 4B_DLS).

Fluorescence Spectroscopy was used to quantify the Nile Red release from the micelles and raw data are provided as .jws files in the folder called Figure 4C 

Generally, every excel sheet or folder is labeled with the specified conditions used and/or with the assigned number of duplicate (typically a and b).