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Data underlying the publication "Equibiaxial and uniaxial cyclic strain similarly affect Notch signaling and vascular smooth muscle cell phenotype in 2D"

DOI:10.4121/6964ba10-be3a-4673-ba90-fb554ec751dd.v1
The DOI displayed above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
DOI: 10.4121/6964ba10-be3a-4673-ba90-fb554ec751dd

Datacite citation style

Karakaya, Cansu; C. van Turnhout, Mark; van den Hurk, Eva A.N.; Bouten, Carlijn V.C.; Sahlgren, Cecilia M. et. al. (2025): Data underlying the publication "Equibiaxial and uniaxial cyclic strain similarly affect Notch signaling and vascular smooth muscle cell phenotype in 2D". Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/6964ba10-be3a-4673-ba90-fb554ec751dd.v1
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite

Dataset

This study explored how strain anisotropy affects mechanosensitive Notch signaling and the resulting phenotype of vascular smooth muscle cells (VSMCs). We applied cyclic strains within the physiological range to compare the effects of equibiaxial and uniaxial loading on Notch activity and phenotypic changes in both synthetic and contractile VSMCs. By assessing three deformation parameters, we aimed to identify the main strain feature influencing these responses. Our findings indicate that VSMCs react similarly to both strain types, suggesting that strain anisotropy may not have a significant impact on Notch signaling and phenotype modulation.


This dataset contains the videos and data for strain analysis, immunofluorescence staining images, and real-time polymerase chain reaction data.

History

  • 2025-05-20 first online, published, posted

Publisher

4TU.ResearchData

Format

strain analysis videos (.avi), strain analysis data (.csv), qPCR data (.csv), fluorescence microscopy images (.tif)

Funding

  • Predicting cardiovascular regeneration: integrating mechanical cues and signaling pathways (grant code 802967) [more info...] European Research Council
  • The integration of cell signalling and mechanical forces in vascular morphology (grant code 771168) [more info...] European Research Council

Organizations

TU Eindhoven, Department of Biomedical Engineering, Eindhoven, The Netherlands
TU Eindhoven, Institute for Complex Molecular Systems, Eindhoven, The Netherlands
Åbo Akademi University, Faculty of Science and Engineering, Turku, Finland

DATA

Files (1)